Ordinarily, all computers would evidently slow down owing to the number of programs installed and running and exposure over the web which injects some files for proper browsing of sites. At some point, boot-up speed of most computers as well as immediate shutdowns as performed by users may encounter some delays. These are only proper since the registry would be open to a lot of modifications from such activities.
This is why some companies have developed registry checkers and cleaners such as Registry Mechanic, to be able to determine the modifications and problems that have affected certain areas of the computer. Among the known issues would be improper deletion of shortcuts or programs without using the add/remove option on the control panel of the Windows operating system. This alone leaves a conflict that makes computers adjust to such occurrences.
Another thing is that of cookies gathered from the web. While cookies are stored in the temporary IE folder of a computer, some may tend to change some configurations on the machine and thus slow it down.
Registry cleaners are not guaranteed to speed up a computer speed at an instant. A user must also thoroughly evaluate if such modifications are okay for removal. A wrong decision may eventually make things worse, hence if a person is unsure, consulting computer experts or even the web for advice prior to action would be advisable.